Rheumatology real-world evidence studies are clinically important, but require careful interpretation
- Real-world evidence studies such as a recent study by Fisher (1) examining the persistence of JAK1/3 inhibitor tofacitinib in patients with RA compared to the persistence of bDMARD of a large, retrospective new user cohort from in a research database, are informative but require cautious interpretation because findings are dependent on a variety of medical and nonmedical influences
- Real-world data are clinically important, and drug survival with appropriate caveats is a good surrogate for continued efficacy and lack of AE necessitating discontinuation
- Confirmation from similar studies in large registries from a variety of countries with differing medical systems would help to clarify the picture and advise on drug persistence of any novel therapy
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SVMPharma is an innovative strategic consultancy, specialising in Real-World Evidence (RWE) for the pharmaceutical industry. SVMPharma generates RWE within UK and Europe through bespoke online Real-World Treatment Evaluators, leading to successful health technology appraisal (HTA) submissions. Clinical trial programmes do not reflect real-world clinical practice and outcomes, RWE supplements and enhances clinical datasets. SVMPharma’s specialist teams focus on delivering the outcomes that matter to your brand.