Emulating control arms for oncology clinical trials using real-world data

  • Trial data was used from published control arm results from 15 trials that supported drug approvals from January 1, 2016, to April 30, 2018
  • RWD cohorts were constructed using a nationwide EHR-derived de-identified database by aligning eligibility criteria and weighting to trial baseline characteristics
  • The trial data and RWD cohorts were compared using Kaplan–Meier and Cox proportional hazards regression models
  • EHR-derived RWD can emulate oncology clinical trial control arm results, although with variability

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About SVMPharma

SVMPharma is an innovative strategic consultancy, specialising in Real-World Evidence (RWE) for the pharmaceutical industry. SVMPharma generates RWE within UK and Europe through bespoke online Real-World Treatment Evaluators, leading to successful health technology appraisal (HTA) submissions. Clinical trial programmes do not reflect real-world clinical practice and outcomes, RWE supplements and enhances clinical datasets. SVMPharma’s specialist teams focus on delivering the outcomes that matter to your brand.

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