Emulating control arms for oncology clinical trials using real-world data

• Trial data was used from published control arm results from 15 trials that supported drug approvals from January 1, 2016, to April 30, 2018
• RWD cohorts were constructed using a nationwide EHR-derived de-identified database by aligning eligibility criteria and weighting to trial baseline characteristics
• The trial data and RWD cohorts were compared using Kaplan–Meier and Cox proportional hazards regression models
• EHR-derived RWD can emulate oncology clinical trial control arm results, although with variability

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About SVMPharma

SVMPharma is an innovative strategic consultancy, specialising in Real-World Evidence (RWE) for the pharmaceutical industry. SVMPharma generates RWE within UK and Europe through bespoke online Real-World Treatment Evaluators, leading to successful health technology appraisal (HTA) submissions. Clinical trial programmes do not reflect real-world clinical practice and outcomes, RWE supplements and enhances clinical datasets. SVMPharma’s specialist teams focus on delivering the outcomes that matter to your brand.

For more information, please visit www.svmpharma.com and contact us at enquiry@svmpharma.com

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