BRUIN trial shows 68% ORR in chronic lymphocytic leukaemia (CLL)

  • “BRUIN is now the largest clinical trial conducted to date that has enrolled CLL/SLL patients previously treated with modern standards of care including BTK and BCL2 inhibitors. In this real-world population of relapsed/refractory patients, pirtobrutinib continues to demonstrate robust activity with a safety profile amenable to chronic administration. Now with the longer follow-up that this analysis affords, we are encouraged by evidence of durable disease control in this very heavily pretreated CLL/SLL population,”

Anthony Mato, M.D., MSCE, director of the CLL Program at Memorial Sloan Kettering Cancer Center

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